ABOUT STRM.BIO

STRM.BIO (“storm bio”) is a pre-clinical, VC-backed biotechnology company that is leveraging extracellular vesicles (EVs) to deliver gene therapies in vivo. We believe in a culture where people come first and that personal accountability is key to a healthy organization. We believe that there is both elegance and efficiency in simplicity, and we let this approach drive both our science and our strategy.

STRM.BIO is located in Cambridge, MA, where we are driving research in our internal laboratory space while simultaneously leveraging the existing laboratory infrastructure and expertise of our scientific collaborators, contract development and manufacturing organizations (CDMOs), and advisors to focus on what matters--our research.

We are assembling a team of leaders who share our company values, who believe in the promise of EVs to bring transformative therapies to patients, and who will actively contribute to a culture of continuous learning, innovative discovery, and unyielding commitment to high quality science.

THE TECHNOLOGY

STRM.BIO is creating a proprietary EV platform to deliver gene therapies in vivo and establish a new class of therapeutics. EVs are natural carriers of nucleic acids and proteins and hold tremendous promise as direct cell messengers for gene therapies due to their innate targeting, tunable loading, and ability to repeat dose. At STRM, we are aiming to create new therapies and uniquely enable effective targeting of existing ones to democratize gene therapy. We are just beginning to explore the potential impact of our platform and are looking to recruit team members who can help us bring this larger vision to light.

THE PERSON AND ROLE

The Process Development Research Associate position is full-time and will be 100% in-person. Your time will be spent designing and conducting experiments and running the company’s proprietary cell culture manufacturing process. You will work directly with the CMC/Process Development team and leadership to execute experiments and generate EV material to support research and development activities.

To be successful in this role, you should be a self-starter, always up for a challenge and find the unique demands of the fast-paced startup environment motivating. You will need to be adept at managing both internal projects and external collaborations and be able to do both while espousing the people-first, simplicity-oriented values we hold as core to STRM culture.

KEY RESPONSIBILITIES

• Perform experiments to help develop a scalable manufacturing process and establish process parameters for Extracellular Vesicle (EV) production
• Independently run processes for cell culture, cell clarification, and Tangential Flow Filtration (TFF) for production, purification, and concentration of EVs
• Perform cargo loading experiments for gene therapy applications
• Generate EV material to support STRM.BIO research programs
• Work closely with team members (internal and external) to maintain project timelines, implement and troubleshoot experiments, and ensure deliverables for both internal research projects and external scientific partnerships
• Attend and present at team meetings to share results and plan projects and experiments
• Maintain standards consistent with company culture and values
• Perform other duties as assigned, including all those associated with facilitating smooth laboratory operations

QUALIFICATIONS & EXPERIENCE

Required

• B.Sc. with 2+ years of biology laboratory experience in a relevant discipline with strong foundational knowledge of biology and engineering fundamentals
• Attention to detail and the ability to work individually, within a multi-disciplinary team in a matrix environment, as well as with external partners and vendors
• Action oriented, results driven, and able to accomplish project objectives on a defined schedule
• Proficiency with Microsoft Office suite, with excellent PowerPoint and Excel skills
• Exceptional communication, writing, organizational and time management skills
• Exemplary lab notebook practices, and attention to detail in recordkeeping

Preferred

• Experience in mammalian cell culture and downstream purification
• Familiarity with extracellular vesicle isolation, evaluation, and manipulation
• Basic knowledge of cell culture manufacturing principles, risk assessments (FMEA), Chemistry, Manufacturing, and Controls (CMC) principles, and tech transfer
• Experience with electronic lab notebooks (ELNs)

KEY POSITION DETAILS

• Full-time Position
• Salary and benefits consistent with the competitive market of Boston/Cambridge and commensurate with experience
• In-person benchwork in Boston/Cambridge area and/or at partner headquarters location(s)