Engineering Intern/Co-Op (2026-2027)

XGenomes
XGenomes

Intern

Cambridge, MA, USA

Posted on Aug 28, 2026
XGenomes is developing a radically new DNA sequencing technology that will revolutionize personalized healthcare. We watch single-molecule interactions at optical super-resolution, down to a few nanometers and use artificial intelligence to decode sequence and epigenetic states. To scale up our prototype, we are looking for a mechatronics/mechanical/systems engineer to join our team for an in-person internship in Cambridge, MA. We look forward to reading your application at this link! What you'll do: Develop and evaluate performance of heating and cooling systems for automated fluidics system for a prototype single-molecule DNA imaging platform. Integrate and control new fluidic components, such as pumps or thermocouples. Test system reliability across device subsystems including fluidics, hardware, and software. Implement work-flows and features in Python-based control software. Work with our biologists to improve experiment reliability and develop new features. Required qualifications: Massachusetts resident, or attending an accredited college/university located in Massachusetts or a Minority Serving Institution. Experience building, validating, and troubleshooting heating and cooling systems. Ability to conduct calibration, testing, and maintenance of instrument subsystems, such as pumps, solenoids, thermocouples. Ability to use CAD tools (Solidworks, Fusion360) and 3D printing or laser cutting technologies to redesign and prototype instrument subsystems. Willingness to learn new skills, communicate across multi-disciplinary team, and document progress. Preferred / bonus experience: Ability to develop embedded systems using Python, serial, Arduino, etc. Experience with microfluidics theory and fabrication. Familiarity with DNA/RNA, biology, or chemical laboratory work.